Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Doenja Hertog 1. Cases Series. Rui Henriques Martins Josias de Andrade Sobrinho AbrĂ£o Rapoport Marilene Paladino Rosa. Histopathologic features and management of .

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On conventional radiographs the ameloblastoma may present as a unilobular or multilobular corticated radiolucency. Histopathologic features and management of ameloblastoma: OncologyOral and maxillofacial surgery. However, in the intramural variants which show invasion into the cyst wall is thought represent a typical ameloblastoma and warrants a more aggressive treatment.

The radiographic differential diagnosis includes a variety of odontogenic cysts and tumours, particularly the keratocystic odontogenic tumour, as well as nonodontogenic cysts and tumours, such as a central giant cell lesion, histopatholoby lesions and simple bone cyst.

It is known that socioeconomic conditions have a major impact on demographic as well as amelobastoma clinical outcome Symptoms include painless swelling, facial deformity if severe enough, pain if the swelling impinges on other structures, loose teeth, ulcers, and periodontal gum disease. The mean follow-up of the patients amounted 8. Since no primary desmoplastic ameloblastomas were encountered in the present study no further comments can be made on this apparently rare entity.


Photomicrographs depicting compressed epithelial islands surrounded by dense fibrous stroma with evidence of bone formation. The diagnosis histopathologg to be confirmed by a biopsy, but occasionally in cystic variants it may be made only after excision. Of the remaining 35 patients data on age, gender, localization, radiographs, type of treatment and recurrences were retrieved from the files Table 1.


Extra-osseous occurrence is rather exceptional.

However, this term has become obsolete and has to be avoided. A review of cases from the literature.

Histopathologic features and management of ameloblastoma: study of 20 cases

In our series the demographical data were in accordance with the results of other studies. Columnar cells surrounding stellate reticulum.

Odontogenic ameloblastoma OA of the jaws is a rare neoplasia of the oral cavity 0. Ameloblastoma is tentatively diagnosed through radiographic examination and must be confirmed by histological examination e.

Robinson has defined it as: The results are shown in Table 2 and Table 3. Cystic lesion lined by epithelium which exhibits columnar differentiation and reverse jistopathology of the basal cell layer.

Adenomatoid odontogenic tumor Keratocystic odontogenic tumour. Wikimedia Commons has media related to Ameloblastoma. Malignant ameloblastomas are extremely rare. This section needs additional citations for verification. They usually occur in middle age group i. Parts of the epithelial lining of a uni cystic ameloblastoma may lack the pathognomonic features an ameloblastoma. There are no specific genetic alteration reported that indicate an increase risk in development of ameloblastoma.

Table 2 shows that there amelolastoma a predominance of white patients over black ones: Wagstaffe gave the first histological drawing. Arch Otolaryngol Head Neck Surg. Unicentric, nonfunctional, intermittent in growth, anatomically benign and clinically persistent.

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Gistopathology is a tumor of the enamel organ without formation of enamel.

Another excluded patient was diagnosed with a metastasis of a previously treated cutaneous basal cell carcinoma, extending into the cortical bone of the mandible and mimicking an ameloblastoma.


There were no significant differences between the clinical parameters of the different types of ameloblastoma in comparison with the data from the literature It is tempting to speculate that the desmoplastic type mainly or perhaps even exclusively occurs in cases of recurrence.

Management of a recurrent follicular ameloblastoma. Among these cases, the location affected was the mandible in 27 cases and the maxilla in 2 cases, whose ages ranged from 20 to 30 years old, comprising 16 blacks and 13 whites, 14 females and 15 males.

Bony septae may result in a honeycomb appearance. Acta Pathol Microbiol Scand A. Head and neck tumors. Epub Oct Two histopathological variants are recognized, aeloblastoma the luminal variant and the mural variant 3 Fig. According to Vasan, 5 the follicular type consists of discrete epithelial lines in a conjunctive tissue stroma and the plexiform consists of a continuous line of anastomosis. Unicystic ameloblastoma luminal typeshowing ameloglastoma epithelial lining the “cyst” wall H.

While these tumors are rarely malignant or metastatic that is, they rarely spread to other parts of the bodyand progress slowly, the resulting lesions can cause severe abnormalities of the face and jaw.

Dalati T, Zhou H. Additionally, squamous cells with abundant cytoplasm and central nucleus can also be seen if there is evidence of squamous metaplasia. Archived from the original on Published online Dec 6. Follicular ameloblastoma figure 1.