Hydranencephaly after Maternal Butane-gas Intoxication during Pregnancy . Hydranence’phalie apr.?s intoxication maternelle par le gaz butane durant la. Autoerotic Accident by Inhalation of Propane-Butane Gas Mixture Toxicologic investigations revealed an intoxication with propane and butane .. kan ve doku örneklerinde gaz komponentlerinin analizinin yap›labilmesi tan›. Butane is a colourless and flammable gas with a gasoline-like or natural gas This paper discusses the medico-legal approach for this type of intoxication.
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Hydroxylation of aliphatic compounds by liver microsomes, I.
The study by Stoughton and Lamson provides a no-observedadverse-effect level for lethality in mice exposed to butane for 2 h. Froth was present in the trachea and bronchi; pulmonary edema was also reported.
No data other than that described in Sections 3. The anoxic nature of the insult zyxwvu zyxwvu Accepted for publication 30th September Retrieved 20 September The relationship between concentration and duration of exposure as related to lethality was examined by ten Berge intoxixation al.
Butane | C4H10 – PubChem
No adequate human data relevant to AEGL-2 effects were found. Help Center Find new research papers in: Therefore, the AEGL-2 values for 30 min and 1, 4 and 8 h are set equal to the 2-h concentration.
Ultraschall- und neuroradiologische Untersuchungen CT Scan und Angiographie zeigten ein fast vollstandiges Fehlen beider Hirnhemispharen. It is difficult to calculate the dosage of butane being consumed by users so effects can vary between individuals.
Butane is produced from raw natural gas and from petroleum streams obtained by catalytic cracking, catalytic reforming, and other refining processes. He was known to inhale butane from a plastic bag.
Basilar artery double arrow and a toxic gas, usually carbon monoxide vertebrobasilar system are normal. Cranial computed tomography revealed two fluid-filled cavities separated by a complete midline falx cerebri Fig.
Butane – Drug and Alcohol Information and Support in Ireland –
Postgrad Med J ; Cardiopulmonary resuscitation was needed. Propane and isobutane were also detected. Neurotoxicity Several case reports of intentional butane exposure indicate that butane induces neurotoxicity. Suffocation and Asphyxia, in: A CT scan at 7 days post-partum revealed an almost complete absence of intoxiication cerebral hemispheres in the newborn.
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BH 3 special conditionscovalent metalloid hydride Right: Huge exposure concentrations can be assumed in butane abuse. The predominant effects observed in abuse cases are central nervous system CNS and cardiac effects. The amniotic fluid was meconium-stained. Four human subjects 3 male, 1 female; years of age were exposed to butane at ppm for 4 h. Her son was delivered at 36 weeks and was severely affected, dying 11 zyxwvutsrq slightly diminished, but occasionally the baby had a high-pitched cry butame tremors in response to stimuli.
However, tissue concentrations of butane in rats were not hutane after a 2-h exposure and the reported brain concentration could already have been reached with a shorter exposure duration.
However, the mice were probably exposed in a closed-chamber setting and the reported butane concentrations might refer to initial concentrations. In another case of butane abuse, a swollen brain was observed in a year-old girl without a history of butane abuse Williams intoxocation Colewhile a CT head scan showed no abnormalities in a year-old male with a 3-year history of butane butsne Edwards and Wenstone Tetracarbane never recommended .
No further details were given. Butane was reported to cause cardiac sensitization gqz dogs, but the studies did not provide detailed information on exposure concentrations and duration or were performed on anesthetized dogs. The relative anesthetic activity of the butanes and pentanes; pp. Several case reports of intentional butane exposure indicate that butane induces neurotoxicity. Ventricular fibrillation induced by hydrocarbons and epinephrine; pp.
Suicide by Inhalation of Suffocative Gas
Death was attributed to multiple organ failure involving the CNS brain edemacardiovascular system, pulmonary system, and the liver. A total uncertainty factor of 3 is considered sufficient for toxicokinetic and toxicodynamic differences between individuals and interspecies differences. Suicide by propane-butane inhalation.
Neurotoxicity No data other than gza described in Sections 3. Developmental and Reproductive Toxicity A pregnant year-old woman accidentally inhaled butane in during week 27 of her pregnancy. However physical withdrawal has been reported among some users. The AEGL-2 values for butane are based on a study with guinea pigs exposed to butane for 2 h at concentrations between 50, and 56, ppm Nuckolls The relationship of hydranencephaly with multicystic encephalomalacia has been stressed repeatedly Lindenberg and SwansonAicardi et al.
Groups of mice sex and strain not haz were exposed to butane at concentrations of , , , orppm; 6 mice were tested at the lowest concentration, and 10 mice at each of the higher concentrations Stoughton and Lamson Butane caused hemodynamic effects in anesthetized dogs but considering the exposure conditions of the study it cannot be used as a basis for setting AEGL values.
The different exposure duration for the two species was based on a comparison of the ratio of minute ventilation volume of gas exchanged from the lungs per minute to body weight, which is approximately two-fold greater in mice.