Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Composition chimique et isolement des deux principaux constituants. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. Cineeea extraction was achieved during six hours and the obtained oil yield 0. Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their cotul against tumor cell lines.

Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy. The two tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: Table of Contents Alerts.

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Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot. View at Google Scholar F.

From Wikipedia, the free encyclopedia. These plants are widely used in the Moroccan traditional folk medicine. The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively. In an ongoing program aimed at xinerea exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.


Retrieved 24 August Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity.

Cotula vulgaris Levyns Cotula zeyheri Fenzl. Sports Turf Research Institute. Furthermore, natural products could cotuls as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs.

TrekNature | Cotula cinerea Photo

In the genus was subdivided by George Bentham [5] into three sections. Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor.

To date various bioactive compounds have been tried against cancer. Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae. After 24 h incubation, cells were then treated with the essential oil of Xotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca. The exact mechanism through which the cotyla extracts act on each tumor cell line is obviously difficult to highlight.

References Publications referenced by this paper. Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.


Flavonoids from Cotula cinerea Del

Then, solvents of the different obtained extracts were cinreea and the dried residues were used to explore their cytotoxic effect. Cotula australis Sieber ex Spreng. From This Paper Figures, tables, and topics from this paper. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al.

The essential oil and the ethyl acetate extract showed moderate cytotoxic effects The collected aerial parts were left under shade at room temperature until complete drying. The Royal Society of New Zealand. In the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest IC 50 value The genus can only be defined by looking at the corollas of their flowers.

The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products. Skip to search form Skip to main content. In the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the n -butanol extract.